Head to Head

REGN vs SEPN: which is the better buy in 2026?

On Alexandria's Compass, Septerna, Inc. has the edge with a 89/100 score versus 88/100 for REGN. Here is how they stack up, factor by factor.

Regeneron Pharmaceuticals

NASDAQ:REGN

88/100 Compass
True NorthAccumulate$86.6B

Dupixent's global dominance and a deep late-stage pipeline make REGN a rare large-cap biotech trading below its growth rate.

Full REGN analysis

Septerna, Inc.

NASDAQ:SEPN

Edge
89/100 Compass
True NorthAccumulate$2.1B

First credible oral GPCR pipeline since the gold rush, with Novo Nordisk paying the bills and a 2026 Phase 2 readout that resets the floor.

Full SEPN analysis

Factor by factor

FactorREGNSEPN
Revenue Growth4398
Profitability8536
Valuation7662
Momentum8977
Theme Purity7058
Moat9050
Catalysts6463
Market Position7648

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Frequently asked questions

Is REGN or SEPN the better buy in 2026?

By Compass Score, Septerna, Inc. (NASDAQ:SEPN) edges it at 89/100 versus 88/100 for REGN. Both scores update weekly and reflect a contrarian, forward-looking read, not a recommendation.

How does Alexandria compare REGN and SEPN?

Each company is scored 1-100 on eight factors: revenue growth, profitability, valuation, momentum, theme purity, moat, catalysts, and market position. The Compass Score is the composite, and the comparison below shows where each name wins factor by factor.

Compass Scores are proprietary editorial research from publicly available data, not investment advice or a recommendation regarding any security. Rankings update weekly.