Head to Head

SEPN vs URGN: which is the better buy in 2026?

On Alexandria's Compass, UroGen Pharma Ltd. has the edge with a 90/100 score versus 89/100 for SEPN. Here is how they stack up, factor by factor.

Septerna, Inc.

NASDAQ:SEPN

89/100 Compass
True NorthAccumulate$2.1B

First credible oral GPCR pipeline since the gold rush, with Novo Nordisk paying the bills and a 2026 Phase 2 readout that resets the floor.

Full SEPN analysis

UroGen Pharma Ltd.

NASDAQ:URGN

Edge
90/100 Compass
True NorthAccumulate$2.5B

Zusduri is rewriting how urologists treat bladder cancer, and the early script data is louder than the share price suggests.

Full URGN analysis

Factor by factor

FactorSEPNURGN
Revenue Growth9898
Profitability3648
Valuation6250
Momentum7789
Theme Purity5858
Moat5050
Catalysts6363
Market Position4848

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Frequently asked questions

Is SEPN or URGN the better buy in 2026?

By Compass Score, UroGen Pharma Ltd. (NASDAQ:URGN) edges it at 90/100 versus 89/100 for SEPN. Both scores update weekly and reflect a contrarian, forward-looking read, not a recommendation.

How does Alexandria compare SEPN and URGN?

Each company is scored 1-100 on eight factors: revenue growth, profitability, valuation, momentum, theme purity, moat, catalysts, and market position. The Compass Score is the composite, and the comparison below shows where each name wins factor by factor.

Compass Scores are proprietary editorial research from publicly available data, not investment advice or a recommendation regarding any security. Rankings update weekly.